Wuhan University
ABOUT US
MinGroup at Wuhan University focuses on medicinal chemistry, anticancer drug discovery, targeted protein degradation, and innovative organic synthesis.We develop new chemical strategies to create, optimize, and evaluate bioactive small molecules, with a particular interest in natural-product-inspired drug discovery, targeted degraders, scaffold hopping, and molecular editing for lead optimization
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Identification of Novel Dual-Target Estrogen Receptor α Degraders with Tubulin Inhibitory Activity for the Treatment of Endocrine-Resistant Breast Cancer
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Discovery of Novel ERα and Aromatase Dual-Targeting PROTAC Degraders to Overcome Endocrine-Resistant Breast Cancer
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Skeletal Editing from Pyridine to Aniline via C-Insertion and N-Isomerization
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Scaffold Hopping of α,β-Unsaturated Ketones via Divergent Alkyl Amine Insertion
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Divergent Skeletal Editing of Pyridinium Salts to Azepinones and Pyrrolidinones via Formal Carbonyl Insertion
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Aminophthalimide as a Protected Nitrogen Source for N-Insertion to Indenones
Email: changmin@whu.edu.cn
QQ Group:
Openings: visiting scholars, Postdoc, graduate students, and undergraduate students